Margaret S. Bynoe

Professor
Microbiology and Immunology, College of Veterinary Medicine

Contact Information

C5 165 Veterinary Medical College
Cornell University
Ithaca, NY 14853
p: (607) 253-4023

Margaret S. Bynoe

Professor
Microbiology and Immunology, College of Veterinary Medicine

Expertise

Blood brain barrier, structure and function; inflammatory bowel diseases; mechanisms of immune cells’ breach of central nervous system barriers; mechanisms of adenosine/adenosine receptor axis regulation of inflammation; mechanism of the gut-brain axis

Current Research Interest

Mechanisms of neurotropic pathogens’ influence on the brain and neurodegenerative diseases; trafficking of multi-drug resistant transporters; multi-modal regulation of A2A adenosine receptor, protein structure/function; role of A1 and A2A adenosine receptors in multiple sclerosis

Distinction

Pfizer Animal Health Award for Research Excellence
Albert Einstein College of Medicine, Graduate Programs in Biomedical Sciences, Fourth Annual PREP Regional Symposium Keynote Speaker
American Association for Immunologists Lustgarten-eBioscience Memorial Award
Cornell University Schwartz Alumni Research Fund Award

Selected Publications

Torres, Luisa, Sudie-Ann Robinson, Do-Geun Kim, Angela Yan, Thomas A. Cleland, and Margaret S. Bynoe. “Toxoplasma Gondii Alters NMDAR Signaling and Induces Signs of Alzheimer’s Disease in Wild-Type, C57BL/6 Mice.” Journal of Neuroinflammation 15, no. 1 (2018): 57.

Kim, Do-Geun and Margaret S. Bynoe. “A2A Adenosine Receptor Modulates Drug Efflux Transporter P-glycoprotein at the Blood-Brain Barrier.” The Journal of Clinical Investigation 126, no. 5 (2016): 1717-1733.

Cornell Research Website Article

Blood-Brain Barrier, Protecting the Brain