Lorraine J. Gudas

Revlon Pharmaceutical Professor of Pharmacology and Toxicology; Chairman, Department of Pharmacology
Pharmacology, Weill Cornell Medicine

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Patricia A. Kuharic

Contact Information

1300 York Avenue, Room E-405
Weill Cornell Medicine
New York, NY 10065
p: (212) 746-6262

Lorraine J. Gudas

Revlon Pharmaceutical Professor of Pharmacology and Toxicology; Chairman, Department of Pharmacology
Pharmacology, Weill Cornell Medicine

Expertise

Epigenetics of stem cell differentiation; retinoid pharmacology; head and neck squamous cell carcinoma; mitochondrial function in kidney cancer

Current Research Interest

Development of new drugs for inhibition of renal cell carcinogenesis; understanding how RARb2 activation reduces the pathology associated with type 2 diabetes and NAFLD (non-alcoholic fatty liver disease); discovering the mechanisms by which vitamin A deficiency causes diabetes; elucidating the mechanisms by which normal stem cells become cancer stem cells in head and neck carcinoma

Distinction

The Future of Health Technology Award
Association for Medical School Pharmacology Chairs, Executive Council (2011-2016)
American Association for the Advancement of Science Fellow
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Board of Scientific Counselors
American Association of Cancer Research Women in Cancer Research Annual Award
National Heart, Lung, and Blood Institute (NHLBI) Board of Scientific Counselors 

Selected Publications

Minton, Denise R., Leiping Fu, Nigel P. Mongan, Maria M. Shevchuk, David M. Nanus, and Lorraine J. Gudas. “Role of NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex 4-like 2 in Clear Cell Renal Cell Carcinoma.” Clinical Cancer Research 22, no. 11 (2015): 2791-2801.

Trasino, Steven E., Yannick D. Benoit, and Lorraine J. Gudas. “Vitamin A Deficiency Causes Hyperglycemia and Loss of Pancreatic β-Cell Mass.” Journal of Biological Chemistry 290, no. 3 (2014): 1456-1473.

Cornell Research Website Article

Retinoids' Extraordinary Potential