Cornell Research Cornell.edu

Expertise
Cell metabolism; cell signaling; cancer biology; biochemistry; molecular biology; physiology

Current Research Interest
Further elucidating the role of PI-3-kinase in anabolic signaling by insulin, IGF-1, and other growth factors; metabolic regulation and oncogenic transformation; NRF2 and the serine pathway; Vitamin C as a potential treatment for RAS-mutant tumors; identifying biomarkers and novel therapeutic targets; drug development and delivery 

Distinction
OncLive Giants of Cancer Care Honor
National Cancer Institute Outstanding Investigator Award
Wolf Prize in Medicine
Canada Gairdner International Award
Breakthrough Prize in Life Sciences
American Academy of Arts and Sciences
National Academy of Sciences
National Academy of Medicine
European Life Sciences Academy EMBO
Ross Prize in Molecular Medicine

Selected Publications
Yun, Jihye, Edouard Mullarky, Changyuan Lu, Kaitlyn N. Bosch, Adam Kavalier, Keith Rivera, Jatin Roper, Iok In Christine Chio, Eugenia G. Giannopoulou, Carlo Rago, Ashlesha Muley, John M. Asara, Jihye Paik, Olivier Elemento, Zhengming Chen, Darryl J. Pappin, Lukas E. Dow, Nickolas Papadopoulos, Steven S. Gross, Lewis C. Cantley. "Vitamin C Selectively Kills KRAS and BRAF Mutant Colorectal Cancer Cells by Targeting GAPDH." Science (2015).

DeNicola, Gina M., Pei-Hsuan Chen, Edouard Mullarky, Jessica A. Sudderth, Zeping Hu, David Wu, Hao Tang, Yang Xie, John M. Asara, Kenneth E. Huffman, Ignacio I. Wistuba, John D. Minna, Ralph J. DeBerardinis, and Lewis C. Cantley. "NRF2 Regulates Serine Biosynthesis in Non-Small Cell Lung Cancer." Nature Genetics (2015). 

Cornell Research Website Video
Solving Cancer through Collaboration