Cornell Research Cornell.edu

Expertise

Cell metabolism; cell signaling; cancer biology; biochemistry; molecular biology; physiology

Current Research Interest

Further elucidating the role of PI-3-kinase in anabolic signaling by insulin, IGF-1, and other growth factors; metabolic regulation and oncogenic transformation; NRF2 and the serine pathway; Vitamin C as a potential treatment for RAS-mutant tumors; identifying biomarkers and novel therapeutic targets; drug development and delivery 

Distinction

Wolf Prize in Medicine
Canada Gairdner International Award
Breakthrough Prize in Life Sciences
American Academy of Arts and Sciences
National Academy of Sciences
National Academy of Medicine

Selected Publications

Bakhoum, Samuel F., Bryan Ngo, Ashley M. Laughney, Julie-Ann Cavallo, Charles J. Murphy, Peter Ly, Pragya Shah, Roshan K. Sriram, Thomas B. K. Watkins, Neil K. Taunk, Mercedes Duran, Chantal Pauli, Christine Shaw, Kalyani Chadalavada, Vinagolu K. Rajasekhar, Giulio Genovese, Subramanian Venkatesan, Nicolai J. Birkbak, Nicholas McGranahan, Mark Lundquist, Quincey LaPlant, John H. Healey, Olivier Elemento, Christine H. Chung, Nancy Y. Lee, Marcin Imielenski, Gouri Nanjangud, Dana Pe’er, Don W. Cleveland, Simon N. Powell, Jan Lammerding, Charles Swanton, and Lewis C. Cantley. “Chromosomal Instability Drives Metastasis Through a Cytosolic DNA Response.” Nature 553 (2018): 467-472.

Liu, Hui, Charles J. Murphy, Florian A. Karreth, Kristina B. Emdal, Forest M. White, Olivier Elemento, Alex Toker, Gerburg M. Wulf, and Lewis C. Cantley. “Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple Negative Breast.” Cancer Discovery 8, no. 3 (2018):354-369.

Cornell Research Website Video

Solving Cancer through Collaboration