John Abbott
Lewis C. Cantley
Professor of Cancer Biology in Medicine
Medicine/Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine
Contact Information
413 East 69th Street, Room 1362, Box 50
Weill Cornell Medicine
New York, NY 10021
p:
(646) 962-6132
f:
(646) 962-0575
Lewis C. Cantley
Professor of Cancer Biology in Medicine
Medicine/Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine
Expertise
Cell metabolism; cell signaling; cancer biology; biochemistry; molecular biology; physiology
Current Research Interest
Further elucidating the role of PI-3-kinase in anabolic signaling by insulin, IGF-1, and other growth factors; metabolic regulation and oncogenic transformation; NRF2 and the serine pathway; Vitamin C as a potential treatment for RAS-mutant tumors; identifying biomarkers and novel therapeutic targets; drug development and delivery
Distinction
Wolf Prize in Medicine
Canada Gairdner International Award
Breakthrough Prize in Life Sciences
American Academy of Arts and Sciences
National Academy of Sciences
National Academy of Medicine
Selected Publications
Paddock, Marcia N., Seth J. Field, and Lewis C. Cantley. “Treating Cancer with Phosphatidylinositol-3-kinase Inhibitors: Increasing Efficacy and Overcoming Resistance.” Journal of Lipid Research 60 (2019): 747-752.
Ferguson, Fleur M., Zainab M. Doctor, Scott B. Ficarro, Christopher M. Browne, Jarrod A. Marto, Jared L. Johnson, Tomer M. Yaron, et al. “Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity.” Cell Chemical Biology 26, no. 6 (2019): 804-817.