Chemical biology; enzymology; biochemistry; enzyme inhibitors; signal transduction
Current Research Interest
Discovering and understanding novel protein modifications by studying orphan enzymes; developing enzyme inhibitors as therapeutic candidates for treating human diseases; using chemical technology to understand cellular signal transduction pathways
Howard Hughes Medical Institute Investigator
Pfizer Award in Enzyme Chemistry
Jing, Hui, Jing Hu, Bin He, Yashira L. Negrón Abril, Jack Stupinski, Keren Weiser, Marisa Carbonaro, Ying-Ling Chiang, Teresa Southard, Paraskevi Giannakakou, Robert S. Weiss, and Hening Lin. “A SIRT2-Specific Inhibitor Promotes c-Myc Oncoprotein Degradation and Inhibits Tumor Growth.” Cancer Cell 29 (2016): 297–310.
Jiang, Hong, Saba Khan, Yi Wang, Guillaume Charron, Bin He, Carlos Sebastian, Jintang Du, Ray Kim, Eva Ge, Raul Mostoslavsky, Howard C. Hang, Quan Hao, and Hening Lin. "Sirt6 Regulates TNF-alpha Secretion through Hydrolysis of Long-Chain Fatty Acyl Lysine." Nature 496 (2013).
Cornell Research Website Article
Seven Sirtuins and Anticancer Activities