Frederick R. Maxfield

Biochemistry, Weill Cornell Medicine

Contact Information

1300 York Avenue, Room E-215
Weill Cornell Medicine
New York, NY 10065
p: (212) 746-6405
(212) 746-8875

Frederick R. Maxfield

Biochemistry, Weill Cornell Medicine


Optical microscopy and biophysical techniques; digital imaging devices; confocal microscopes; multiphoton microscopy; automated microscopy systems; and image processing computers for analyzing processes that occur at specific sites within cells

Research Interest

Lipid and protein trafficking in cells, atherosclerosis, macrophages, microglial biologogy, degradation of Alzheimer's amyloid

Selected Publications

Solé-Domènech, Santiago, Ana V. Rojas, Gia G. Maisuradze, Harold A. Scheraga, Peter Lobel, and Frederick R. Maxfield. “Lysosomal Enzyme Tripeptidyl Peptidase 1 Sestabilizes Fibrillar Amyloid-Beta by Multiple Endoproteolytic Cleavages within the ß-Sheet Domain.” Proceedings of the National Academy of Sciences USA 115, no. 7 (2018): 1493-1498.

Singh, Rajesh K., Valéria C. Barbosa-Lorenzi, Frederik W. Lund, Inna Grosheva, Frederick R. Maxfield, and Abigail S. Haka. (2016) “Degradation of Aggregated LDL Occurs in Complex Extracellular Sub-Compartments of the Lysosomal Synapse.” Journal of Cell Science 129 (2016): 1072-1082.

Cornell Research Website Article

Clearing Out the Waste