Ari M. Melnick

Gebroe Family Professor of Hematology/Oncology; Director, Sackler Center for Biomedical and Physical Sciences
Joan and Sanford I. Weill Department of Medicine/Pharmacology, Weill Cornell Medicine

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Ari M. Melnick
Patricia Kuharic

Contact Information

BB-1462 413 East 69th Street
Weill Cornell Medicine
New York, NY 10021
p: (646) 962-6725

Ari M. Melnick

Gebroe Family Professor of Hematology/Oncology; Director, Sackler Center for Biomedical and Physical Sciences
Joan and Sanford I. Weill Department of Medicine/Pharmacology, Weill Cornell Medicine

Expertise

Biology of the immune system; lymphomas and leukemias; epigenetics; cancer experimental therapeutics

Current Research Interest

Mechanisms through which the epigenome programs the normal immune response; how mutations in epigenetic modifier genes causes lymphoma; the molecular epigenetic blueprints that determine the biology of acute leukemias; novel therapeutic agents and regimens for patients with lymphomas and leukemias

Distinction

Sidney Kimmel Foundation Scholar in Cancer Research
Leukemia and Lymphoma Society Scholar
American Society of Hematology Scholar Award
Burroughs Wellcome Fund Clinical Scientist Award in Translational Research
American Society of Clinical Investigation
Association of American Physicians

Selected Publications

Béguelin, Wendy, Marín A. Rivas, María T. Calvo Fernández, Matt Teater, Alberto Purwada, David Redmond, Hao Shen, Matt F. Challman, Olivier Elemento, Ankur Singh, and Ari M. Melnick. “EZH2 Enables Germinal Center Formation Through Epigenetic Silencing of CDKN1A and an Rb-E2F1 Positive Feedback Loop.” Nature Communications 8, no.1 (2017): 877.

Jiang, Yanwen, Ana Ortega-Molina, Hsia-Yuan Ying, Huimin Geng, Dylan McNally, Ling Wang, Ashley S. Doane, Xabier Agirre, Matt Teater, Cem Meydan, Zhuoning Li, David Polaway, Sara Parsa, Shenqiu Wang, Daisuke Ennishi, David W. Scott, Rita Shaknovich, Randy D. Gascoyne, Wayne Tam, Olivier Elemento, Hans-Guido Wendel, and Ari M. Melnick. “CREBBP Inactivation Promotes the Development of HDAC3 Dependent Lymphomas.” Cancer Discovery 7, no.1 (2017): 38-53.

Cornell Research Website Article

Figuring out How to Control Cancer