Cornell Research Cornell.edu

Expertise
Structural and biochemical tools to understand the biology of RNA; the determination of crystal structures of RNA and RNA-protein complexes; structure-guided function interrogations

Current Research Interest
CRISRP-Cas mediated RNA interference in bacterial pathogens; structure-function study of Cas proteins in the Type I-C system; Type I-E system; Type I CRISPR-Cas systems

Selected Publications
Huo, Yanwu, Ki Hyun Nam, Fang Ding, Heejin Lee, Lijie Wu, Yibei Xiao, F. Daniel Farchione, Sharleen Zhou, Raj Rajashankar, Igor Kurinov, Rongguang Zhang, and Ailong Ke. “Structures of CRISPR Cas3 Offer Mechanistic Insights into Cascade-Activated DNA Unwinding and Degradation.” Nature Structural & Molecular Biology 21, no. 9 (2014): 771–777. doi: 10.1038/nsmb.2875.

Nam, Ki Hyun, Charles Haitjema, Xueqi Liu, Fran Ding, Hongwei Wang, Matthew P. Delisa, and Ailong Ke. “Cas5d Protein Processes Pre-crRNA and Assembles into a Cascade-like Interference Complex in Subtype I-C/Dvulg CRISPR-Cas System.” Structure 20, no. 5 (2012): 1574–1584. doi: 10.1016/j.str.2012.06.016.

Cornell Research Website Article
Genetic Editing with CRISPR