Studying Zebrafish to Understand Motoneuron Behavior
Our ability to move depends on assembling complex neural circuits in the brain that control which muscles are active at particular times to allow effortless movements. Fetcho’s work reveals principles that underlie the development and functional organization of circuits that control movement. By studying transparent zebrafish, the researchers are able to watch the brain as it develops and image the activity of neurons during behavior. Disruptions of circuits associated with injury, disease, and disrupted development lead to many devastating disorders, such as Parkinson's disease, Huntington's disease, paralysis and epilepsy.
Joseph Fetcho’s research aims to understand the developmental and functional rules governing the assembly of circuits in the hindbrain and spinal cord that allow us to move properly and that must be repaired after injury and disease. NIH Grant Number: R01NS026539