Cornell’s Advanced Facility for Studying Biomedicine Topics

New imaging techniques are generating high-resolution structural information about proteins, enabling research on the molecular basis of several diseases. Obtaining information on the structure and function of complex proteins will highlight new therapeutic targets and aid in the development of innovative clinical strategies for dealing with disease. To advance these biomedical research goals, researchers need routine access to technologies for studying the conformation and oligomeric states of biomedically relevant proteins and protein complexes. They also need the capability to improve on available techniques, extending knowledge of complex systems that are not currently understood.

The MacCHESS Synchrotron Source for Structural Biology, led by Richard Cerione, Molecular Medicine, College of Veterinary Medicine/Chemistry and Chemical Biology, College of Arts and Sciences, provides the facilities and technology necessary to generate information on the structure and function of complex proteins and other macromolecules. Work performed at MacCHESS will yield fundamental insights into biology and biomedicine—adding to the understanding of complex membrane receptor-signaling systems, regulation of ion channels in neuronal function, catalytic mechanisms of enzymes, and complex macromolecular assemblies responsible for gene expression.

MacCHESS facilitates the utilization of established and emerging technologies. The facility provides ongoing support to more than 100 investigator projects funded by the National Institutes of Health and other government institutions. Collectively, these efforts will offer unique opportunities for pursuing some of the most challenging questions in structural biology.

NIH Award Number:  1P30GM124166-01A1

Cornell Researchers

Funding Received

$17.3 Million spanning 5 years