About Chronic Inflammation
Inflammation is a vital physiological process in infection and tissue repair after injury. But uncontrolled, chronic inflammation occurs in many diseases, including cancer, colitis, and autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, and Type 1 diabetes. Current anti-inflammatory drugs are delivered systemically and cause off-target effects in otherwise healthy tissues. The major source of inflammation is activation of the immune system, therefore the demand for next-generation technologies to locally inhibit the immune system to limit these side effects is great.
With this Beckman Young Investigator Award, Pamela V. Chang, Microbiology and Immunology, is developing precision chemical tools to inhibit local inflammation by modulating the functions of select target populations of immune cells. These tools will enable the study of fundamental biological mechanisms of inflammatory pathways as well as the control of the immune response in therapeutic settings.