Cancer; muscular dystrophy and heart disease; cellular biomechanics and mechanotransduction; mechanobiology; microfluidics
Current Research Interest
Biophysical processes in cancer cell invasion and metastasis; disease mechanisms by which mutations in nuclear envelope proteins cause muscular dystrophy and dilated cardiomyopathy; in vitro models to study muscle regeneration and cell migration; how cells sense and respond to mechanical forces
National Science Foundation CAREER Award
Scientist Development Grant, American Heart Association
Cardiovascular Leadership Group Investigation Award, Brigham and Women’s Hospital
Lerner Symposium Young Investigator Award, Brigham and Women’s Hospital
Hearst Young Researchers Award, Brigham and Women’s Hospital
Young Innovator in the 2014 Young Innovators Special Edition of Cell and Molecular Bioengineering Journal
Denais, Celine M., Rachel M. Gilbert, Philipp Isermann, Alexandra L. McGregor, Mariska te Lindert, Bettina Weigelin, Patricia M. Davidson, Peter Friedl, Katarina Wolf, and Jan Lammerding. “Nuclear Envelope Rupture and Repair During Cancer Cell Migration.” Science 352, no. 6283 (2016): 353-8.
Ho Chin Yee, Diana E. Jaalouk, Maria K. Vartiainen, and Jan Lammerding. “Lamin A/C and Emerin Regulate MKL1/SRF Activity by Modulating Actin Dynamics.” Nature 497, no. 7450 (2013): 507-11.
Cornell Research Website Article
Cell Mechanics, Cancer, and Muscle Disease