Lorraine J. Gudas
Epigenetics of stem cell differentiation; retinoid pharmacology; head and neck squamous cell carcinoma; mitochondrial function in kidney cancer
Current Research Interest
Development of new drugs for inhibition of renal cell carcinogenesis; understanding how RARb2 activation reduces the pathology associated with type 2 diabetes and NAFLD (non-alcoholic fatty liver disease); discovering the mechanisms by which vitamin A deficiency causes diabetes; elucidating the mechanisms by which normal stem cells become cancer stem cells in head and neck carcinoma
The Future of Health Technology Award
Association for Medical School Pharmacology Chairs, Executive Council (2011-2016)
American Association for the Advancement of Science Fellow
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Board of Scientific Counselors
American Association of Cancer Research Women in Cancer Research Annual Award
National Heart, Lung, and Blood Institute (NHLBI) Board of Scientific Counselors
Minton, Denise R., Leiping Fu, Nigel P. Mongan, Maria M. Shevchuk, David M. Nanus, and Lorraine J. Gudas. “Role of NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex 4-like 2 in Clear Cell Renal Cell Carcinoma.” Clinical Cancer Research 22, no. 11 (2015): 2791-2801.
Trasino, Steven E., Yannick D. Benoit, and Lorraine J. Gudas. “Vitamin A Deficiency Causes Hyperglycemia and Loss of Pancreatic β-Cell Mass.” Journal of Biological Chemistry 290, no. 3 (2014): 1456-1473.