John T. Lis

Barbara McClintock Professor of Molecular Biology and Genetics
Molecular Biology and Genetics, College of Agriculture and Life Sciences/College of Arts and Sciences

Contact Information

416 Biotechnology Bldg.
Cornell University
Ithaca, NY 14853
p: (607) 255-2442

John T. Lis

Barbara McClintock Professor of Molecular Biology and Genetics
Molecular Biology and Genetics, College of Agriculture and Life Sciences/College of Arts and Sciences

Expertise

Gene regulation; transcription; chromatin structure; genomics; RNA aptamers

Current Research Interest

Develop genetic, optical, and biochemical approaches to study transcription regulation; understand chromatin and overall nuclear architecture in regulating the genome; develop RNA aptamers as drugs to inhibit macromolecular interactions in cells and to use specifically to elucidate mechanisms of gene regulation

Distinction

American Academy of Arts and Sciences
National Academy of Sciences
Helen Hay Whitney Foundation Postdoctoral Fellowship
National Institutes of Health MERIT Award
John Simon Guggenheim Memorial Foundation Fellowship

Selected Publications

Mahat, Dig B., Herbert H. Salamanca, Fabiana M. Duarte, Charles G. Danko­, and John T. Lis. “Mammalian Heat Shock Response and Mechanisms Underlying Its Genome-wide Transcriptional Regulation.” Molecular Cell 62, no. 1 (2016): 63-78. 

Kwak, Hojoong, Nicholas J. Fuda, Leighton J. Core, and John T. Lis. “Precise Maps of RNA Polymerase Reveal How Promoters Direct Initiation and Pausing.” Science 339, no. 6122 (2013): 950-953.

Cornell Research Website Article

Tools for Observing Gene Transcription