Frederick R. Maxfield
Optical microscopy and biophysical techniques; digital imaging devices; confocal microscopes; multiphoton microscopy; automated microscopy systems; and image processing computers for analyzing processes that occur at specific sites within cells
Lipid and protein trafficking in cells, atherosclerosis, macrophages, microglial biologogy, degradation of Alzheimer's amyloid
Solé-Domènech, Santiago, Ana V. Rojas, Gia G. Maisuradze, Harold A. Scheraga, Peter Lobel, and Frederick R. Maxfield. “Lysosomal Enzyme Tripeptidyl Peptidase 1 Sestabilizes Fibrillar Amyloid-Beta by Multiple Endoproteolytic Cleavages within the ß-Sheet Domain.” Proceedings of the National Academy of Sciences USA 115, no. 7 (2018): 1493-1498.
Singh, Rajesh K., Valéria C. Barbosa-Lorenzi, Frederik W. Lund, Inna Grosheva, Frederick R. Maxfield, and Abigail S. Haka. (2016) “Degradation of Aggregated LDL Occurs in Complex Extracellular Sub-Compartments of the Lysosomal Synapse.” Journal of Cell Science 129 (2016): 1072-1082.
Cornell Research Website Article
Clearing Out the Waste