Chemical biology; enzymology; biochemistry; enzyme inhibitors; regulatory mechanisms of biology
Current Research Interest
Discovering and understanding novel protein modifications by studying orphan enzymes; developing enzyme inhibitors as therapeutic candidates for treating human diseases; using chemical technology to understand regulatory mechanisms of biology
Howard Hughes Medical Institute Investigator
Pfizer Award in Enzyme Chemistry
Jing, Hui, Jing Hu, Bin He, Yashira L. Negrón Abril, Jack Stupinski, Keren Weiser, Marisa Carbonaro, et al. “A SIRT2-Specific Inhibitor Promotes c-Myc Oncoprotein Degradation and Inhibits Tumor Growth.” Cancer Cell 29, no. 3 (2016): 297–310.
Cao, Ji, Lei Sun, Pornpun Aramsangtienchai, Nicole A. Spiegelman, Xiaoyu Zhang, Weishan Huang, Edward Seto, and Hening Lin. “HDAC11 Regulates Type I Interferon Signaling through Defatty-Acylation of SHMT2.” Proceedings of the National Academy of Sciences of the USA 16, no. 12 (2019): 5487-5492.