Biochemistry; structural biology; single molecule biophysics; genome editing
Current Research Interest
CRISPR-Cas mechanism and genome editing applications; bacterial immunity, host-pathogen interaction; RNA structure, function, and gene-regulatory mechanisms
RNA Society Mid-Career Award
Cornell Provost Research Innovation Award in the Life Sciences
Dolan, Adam, Zhonggang Hou, Yibei Xiao, Max Gramelspacher, Jaewon Heo, Sara Howden, Peter Freddolino, Ailong Ke, and Yan Zhang. “Introducing a Spectrum of Long-Range Genomic Deletions in Human Embryonic Stem Cells Using Type I CRISPR-Cas.” Molecular Cell 74, no. 5 (2019): 936-950.
Yibei Xiao, Yibei, Luo Min, Andam E. Dolan, Maofu Liao, and Ailong Ke. “Structure basis for RNA-guided DNA degradation by Cascade and Cas3.” Science 361 (2018): 6397.