Delaying or Preventing Osteoarthritis
David Putnam and Lawrence Bonassar investigate synthetic mimetics of the natural proteoglycan lubricant, lubricin, to delay or prevent progression of osteoarthritis (OA) following injury to the weight-bearing articular cartilage of the knee.
Hyaluronic acid is a polysaccharide, the natural hydrodynamic mode lubricant (fast and light normal load) in the knee. Lubricin is a proteoglycan, the natural boundary mode lubricant (slow and heavy normal load) in the knee. Both hydrodynamic and boundary mode lubrication are essential but not yet clinically available to adequately lubricate the knee and delay or prevent OA progression.
Through testing the researchers want to know whether boundary mode lubrication of the knee can be afforded by synthetic lubricin mimetics and whether intraarticular administration of the mimetics will prevent OA disease progression. Their goal is to identify one or more clinically promising lubricin mimetics with the potential to delay or prevent the onset of osteoarthritis. NIH Grant Number: R01AR066667