Three-dimensional chromatin organization; transcriptional regulation; epigenetics; stem cell biology; induced pluripotent stem cell (iPSC) reprogramming; cell-fate control
Current Research Interest
Delineating the complex epigenetic mechanisms that dictate cell-fate decisions as a means to discover safer and more efficient ways to rationally modulate cell identity for biomedical purposes; pursuing this research through dissecting the critical interplay among epigenetic marks, three-dimensional chromatin organization, and transcription either during maintenance of cell fate (self-renewal) or during transition to a new fate; using state-of-the-art genome-wide chromatin assays and powerful epigenetic engineering tools that enable generation and precise modulation of four-dimensional molecular road maps during cell cycle or cell-fate change
National Institutes of Health Director’s New Innovator Award
Mark Foundation for Cancer Research Emerging Leader Award
Raymond and Beverly Sackler Research Scholar
Jane Coffin Childs Fund Fellow
Pelham-Webb, Bobbie, Alexander Polyzos, Luke Wojenski, Andreas Kloetgen, Jiexi Li, Dafne Campigli Di Giammartino, Theodore Sakellaropoulos, et al. “H3K27ac Bookmarking Promotes Rapid Post-Mitotic Activation of the Pluripotent Stem Cell Program without Impacting 3D Chromatin Reorganization.” Molecular Cell 81, no. 8 (2021): 1732–1748.e8.
Campigli Di Giammartino, Dafne, Andreas Kloetgen, Alexander Polyzos, Yiyuan Liu, Daleum Kim, Dylan Murphy, Abderhman Abuhashem, et al. “KLF4 Is Involved in the Organization and Regulation of Pluripotency-Associated Three-Dimensional Enhancer Networks.” Nature Cell Biology 21 (2019): 1179–1190.